Lepromatous leprosy WebPathology
Lepromatous Leprosy : Clinical Features - WebPatholog
- Lepromatous leprosy is a more systemic and widespread disease as compared to the tuberculoid form and is seen in patients with poor cell-mediated immunity to M. leprae. The antibody titers to M. leprae are high. The skin lesions are multiple, widespread, symmetrical, and firm and include a combination of macules, papules, plaques, and nodules
- Lepromatous leprosy involving the face in the form of multiple infiltrated papules and plaques. Image courtesy of: Dr. Ian McColl; Global Skin Atlas; Used with permission. slide 17 of 38. Advertisement. Tweets by @WebPathology
- Borderline lepromatous leprosy manifests with a large number of skin lesions consisting of plaques and ill-defined infiltrated nodules. Unlike lepromatous leprosy, the lesions are not symmetrical. Nerve trunks are palpably thickened
- Tuberculoid leprosy is seen in patients with a robust cell-mediated immunity which prompts a granulomatous macrophage response. There is preponderance of CD4+ T-helper cells over CD8+ T-suppressor cells and no antibody response to M. leprae
Histologically, the tuberculoid and lepromatous forms have distinct appearances. Lepromatous leprosy is rich with dermal parasitized macrophages, whereas the tuberculoid form is similar to the granulomatous inflammation by which its name is ascribed; epithelioid histiocytes with multinucleated giant cells and a lymphohistiocytic cuff Leishmania is an organism related to the trypanosomes. The inflammatory disease caused by the organism may involve skin and mucous membranes, as well as internal organs Frequent atrophy of adnexal structures, increased fibroblasts, thickening and luminal narrowing of small vessels, blunting of dermal-subcutis interface, diminished elastic tissue. Often atrophy of epidermis, mucin deposition. Variable dystrophic calcification of blood vessels. Control biopsy from adjacent normal skin is helpful
Mutations and overexpression of β catenin are associated with various carcinomas. Colon: plays a critical role in tumorigenesis (mutations in APC or β catenin present in 90% of colon cancers) Thyroid: pathway important for anaplastic and possibly papillary thyroid carciomas ( Front Endocrinol (Lausanne) 2012;3:31 ) Uterus: endometrioid. menjelaskan tentang jenis-jenis parasit dan penyakit yang ditimbulkannya meliputi trematoda, cestoda, nematoda, protozoa dan anthropod MANIFESTATIONS ACCORDING TO TYPE 1)Tuberculoid (mild) Maculo-anaesthetic leprosy n Good immunity n 2)Lepromatous (severe) Nodular leprosy— leonine facies n Low immunity n GROSS n 1)Tuberculoid (mild) Macules (flat hypopigmented patches) n + nerve Inflammation (thickening) n 2)Lepromatous (severe) Nodules or erythematous macules n + nerve.
Borderline Lepromatous Leprosy - WebPatholog
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- istration of prednisone is a common risk factor and cases have been reported following treatment of asthma with glucocorticosteroids. Other risk factors include impaired gut motility, protein-calorie malnutrition, alcoholism, hypochlorhydria, lymphoma, organ transplantation and lepromatous leprosy
- ated infection in which larvae are found in other organs including the liver, kidney and central nervous system. Figure 5.4
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